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White Paper

Thyroid RFA: A 10-Year Clinical Follow-Up

Exploring a Decade of Lasting Relief After Radiofrequency Ablation
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Thyroid RFA: 10-Year Clinical Follow-Up White Paper

A Non-Surgical Approach to Thyroid Nodule Reduction

Radiofrequency ablation (RFA) is fast becoming a safe, proven alternative to thyroidectomy surgery. It’s a non-surgical outpatient technique that has been used to treat benign and malignant thyroid nodules for over 20 years.1-4

This white paper examines the efficacy of RFA at reducing nodule size using Cambridge Interventional’s CRF RFA system, spanning post-treatment evaluations from six months to 10 years.

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Featured CRF RFA Study Highlights

The CRF RFA system has been clinically proven to reduce the size of thyroid nodules.

In Park et al.,5 which studied the efficacy of CRF RFA with 421 patients across a decade, average nodule size was reduced by:

  • 63% after 6 months
  • 81% after 2 years
  • 90% after 5 years
  • 94% after 10 years

A second 10-year study from 2025, Shin et al.,6 further supports these findings, with thyroid nodules reduced by 100% in as little as two years:

  • 40.8% after 6 months
  • 74.6% after 1 year
  • 100% after 2-10 years
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References
  1. Dupuy DE, Monchik JM, Decrea C, Pisharodi L. Radiofrequency ablation of regional recurrence from well-differentiated thyroid malignancy. Surgery. 2001 Dec;130(6):971-7. doi: 10.1067/msy.2001.118708. Erratum in: Surgery. 2022 Apr;171(4):1138. doi: 10.1016/j.surg.2021.12.008.
  2. Kim YS, Rhim H, Tae K, Park DW, Kim ST. Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience. Thyroid. 2006 Apr;16(4):361-7. doi: 10.1089/thy.2006.16.361
  3. Baek JH, Jeong HJ, Kim YS, Kwak MS, Lee D. Radiofrequency ablation for an autonomously functioning thyroid nodule. Thyroid. 2008 Jun;18(6):675-6. doi: 10.1089/thy.2007.0274
  4. Tufano RP, Pace-Asciak P, Russell JO, Suárez C, Randolph GW, López F, Shaha AR, Mäkitie A, Rodrigo JP, Kowalski LP, Zafereo M, Angelos P, Ferlito A. Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid
  5. Park SI, Baek JH, Lee DH, Chung SR, Song DE, Kim WG, Kim TY, Sung TY, Chung KW, Lee JH. Radiofrequency Ablation for the Treatment of Benign Thyroid Nodules: 10-Year Experience. Thyroid. 2024 Aug;34(8):990-998. doi: 10.1089/thy.2024.0082.
  6. Shin JH, Seo M, Lee MK, Jung SL. Radiofrequency Ablation of Benign Thyroid Nodules: 10-Year Follow-Up Results From a Single Center. Korean J Radiol. 2025 Feb;26(2):193-203. doi: 10.3348/kjr.2024.059
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